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艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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Encapsula NanoSciences.jpg

艾美捷科技特约代理Encapsula NanoSciences公司产品。


Encapsula NanoSciences是美国一家致力于提供基于脂质纳米微粒技术(脂质体)的研发和生产的高科技生物纳米技术公司,具有多项知识产权。Encapsula NanoSciences公司现拥有Clodrosome ® , Encapsome ®和Fluoroliposome ® 三个注册商标品牌,提供表面活性脂质体配方和生产服务,包括抗体/多肽交联(Immunosome)、氯磷酸盐脂质体(Clodrosome)及其对照脂质体(Encapsome)、阿霉素脂质体(Doxosome)、DNA和 RNA脂质体 (Genesome)、荧光脂质体(Fluoroliposome)、冻干ATP脂质体(ATPsome)、多款用于人造细胞模型的细胞脂质体(Cellsome)、用于抗肿瘤药物封装的脂质体、多款用于皮肤学及化妆品研发领域的脂质体(Cosmesome) 、以及用于姜黄色素(Curcusome)、肌醇(Inosisome)和宠物专用的营养补充剂脂质体 (Taurosome) 。公司产品服务于学术研究及工业生产等多个领域。通常根据客户需求提供实验室规模的预制脂质体产品。

 

Encapsula NanoSciences is a specialty company focused on providing liposome research, development and manufacturing expertise in the production of lipid-based nanoparticles, also known as liposomes, to clients and partners in both the academic and industrial sectors. Encapsula routinely provides custom laboratory-scale liposome preparations of drug encapsulated liposomes such as Clodrosome® (clodronate liposomes), Encapsome® (plain-control liposomes for clodronate liposomes), Doxosome™ (doxorubicin liposomes), Immunosome™ (reactive liposomes for antibody, protein conjugation), Immunodox™ (reactive liposomes for antibody, protein conjugation containing doxorubicin), Immunogene™ (reactive liposomes for antibody, protein conjugation containing genetic material), Immunofluor™ (reactive liposomes for antibody, protein conjugation containing fluorescent molecules for tracking), Genesome™ (liposomal DNA and RNA), Fluoroliposome™ (fluorescent liposomes), Atpsome™ (ATP liposomes), Cellsome™ (plain liposomes as artificial cell models) and Cosmesome™ (liposomes used in dermatology) to clients in universities and industrial research labs. Encapsula NanoSciences also recently introduced two oral liposomal product lines; NanoLife Nutra for pets and NanoLife Tonics for humans.

 

Encapsula NanoSciences的主要产品包括:

Plain Liposomes as Artificial Cell Models or as Control

Small Molecules Encapsulated into Liposomes

Magnetic Liposomes

Fluorescent Liposomes

Spin labeled Liposomes

Encapsulation of Genetic Materials into the Liposomes

Liposomes used for Electro-Injection

Long-Circulating Sterically Protected Liposomes

Surface Modification of Liposomes

pH Sensitive Liposomes (PSL)

Freeze-Dried Liposomal Systems

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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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艾美捷科技代理Arraybridge品牌全系列产品


Array Bridge 公司由一群在药物发现与生物制品开发领域经验丰富的科学家创立。公司专注于两大方向:生物制品开发与功能蛋白质组学。在生物制品领域,Array Bridge 开发了 "蛋白质构象阵列"(Protein Conformational Array)技术,可在分子层面对生物类似药及新型生物制品的结构相似性进行精准测量,为生物制剂的构象可比性提供高灵敏、系统性且稳健的评估方案。在功能蛋白质组学方向,公司创新推出PEP(蛋白质洗脱板,Protein Elution Plate)技术,该系统通过整合高效的蛋白质洗脱与重折叠流程,实现了对蛋白质组功能性蛋白的系统性检测。该技术融合了二维凝胶蛋白质分离的高分辨率优势,成为绘制功能性蛋白质组图谱的强大工具。

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▍Arraybridge产品线

Array Bridge公司的核心产品包括蛋白组学PEP试剂盒、生物标志物发现、单克隆抗体构象分析、蛋白纯化、检测试剂以及酶活性检测产品。


● 蛋白组学PEP试剂盒


品名中文名称货号
NADPH Oxidases Landscape (Large Format PEP)NADPH 氧化酶组的系统分析(大规格的PEP 平板)试剂盒AB000503
NADH Oxidases Landscape (Large Format PEP)NADH 氧化酶组的系统分析(大规格的PEP 平板)试剂盒AB000502
Protein Kinases Landscape (Large Format PEP)蛋白激酶组的系统分析(大规格的PEP 平板)试剂盒AB000504
Proteinases Landscape (Large Format PEP)蛋白酶组的系统分析(大规格的PEP 平板)试剂盒AB000505
Proteinases Connect (Small Format PEP)蛋白酶族的系列分析(小规格的PEP)试剂盒AB000405
Protein Kinases Connect (Small Format PEP)蛋白激酶族的系列分析(小规格的PEP)试剂盒AB000404
NADH Oxidases Connect (Small Format PEP)NADH 氧化酶族的系列分析(小规格的PEP)试剂盒AB000402
NADPH Oxidases Connect (Small Format PEP)NADPH 氧化酶族的系列分析(小规格的PEP)试剂盒AB000403


● 生物标志物发现

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品名货号
UPCK Buffer Kit  (500 & 1000 ml)AB000625-500
UPCK Elution Buffer UPEB™ (500 & 1000 ml)AB000624-500
UPCK Wash Buffer UPWB™ (500 & 1000 ml)AB000623-500
UPCK Binding Buffer UPBB™ (500 & 1000 ml)AB000622-500
Hemovoid Buffer Kit (500 & 1000 ml)AB000621-500
HemoVoid Elution Buffer HVEB™ (500 & 1000 ml)AB000620-500
HemoVoid Wash Buffer HVWB™ (500 & 1000 ml)AB000619-500
HemoVoid Binding Buffer HVBB™ (500 & 1000 ml)AB000618-500
AlbuVoid Buffer Kit (500 & 1000 ml)AB000617-500
AlbuVoid Elution Buffer AVEB™ (500 & 1000 ml)AB000616-500
AlbuVoid Wash Buffer AVWB™ (500 & 1000 ml)AB000615-500
AlbuVoid Binding Buffer AVBB™ (500 & 1000 ml)AB000614-500
KinaSorb™ (10 & 50 Preps)AB000612-10
UPCK™ Urine Protein Concentration Kit (10 & 25 Preps)AB000611-10
Hemo Trial Kit™AB000606
HemoVoid™ - Blood Card Reagent (10 & 50 Dried Whole Blood Card)AB000609-10
HemoVoid™ (10, 50 & 100 Preps)AB000608-10
HemogloBind™ (15 & 50 ml)AB000607-15
Cleanascite™AB000605-100
BindPro™ Metabolomics (15 & 50 Preps)AB000604-15
AlbuVoid™ (10 & 50 Preps)AB000603-10
AlbuSorb™ (6 & 18 grams)AB000602-6
Albu Trial Kit™AB000601
P53Bridge ELISA KitAB000219
SHP2Bridge ELISA KitAB000220


● 单克隆抗体构象分析

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品名货号
OmaBridge Elisa KitAB00023
SomaBridge ELISA KitAB000217
RabBridge ELISA KitAB000222
MouseBridge ELISA KitAB000221
AfliBridge ELISA Kit (for Eylea Biosimilar Comparison)AB000218
UsteBridge ELISA Kit (for Stelara Biosimilar Comparison)AB000216
GoliBridge ELISA Kit (for Simponi Biosimilar Comparison)AB000215
DenoBridge ELISA Kit (Prolia Biosimilar Comparison)AB000213
LuceBridge ELISA (for Lucentis Biosimilar Comparision)AB000214
FilBridge ELISA (For Filgrastim Biosimilar Comparison)AB000212
EnbrBridge Elisa (for Enbrel biosimilar comparison)AB000211
EpoBridge ELISA (for Erythropoietin Biosimilar comparison)AB000210
RituBridge ELISA (for Rituxan Biosimilar Comparison)AB000204
RemiBridge ELISA (for Remicade Biosimilar comparison)AB000209
ErbiBridge ELISA (for Erbitux Biosimilar Comparison)AB000202
CampBridge ELISA (for Campath Biosimilar Comparison)AB000203
InnoBridge ELISA (for novel monoclonal antibody & other biosimilars with the same Fc sequence)AB000208
HercBridge ELISA (for Herceptin Biosimilar Comparison)AB0002071
SynaBridge ELISA (for Synagis Biosimilar Comparison)AB000206
HumiBridge ELISA (for Humira Biosimilar Comparison)AB000205
AvaBridge ELISA (for Avastin Biosimilar Comparison)AB000201


● 蛋白纯化


品名中文名称货号
PEP Universal Protein Purification Kit -- Large Format蛋白纯化(大规格的PEP 平板)试剂盒AB000501
PEP Universal Protein Purification Kit -- Small Format384 孔通用PEP 平板功能蛋白质纯化试剂盒AB000401


● 检测试剂

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品名货号产品描述
SHP2 ELISAAB000127For the quantitation of SHP2 protein from human tissue, cell lines and other samples (Catalog #: AB000127)
P53 ELISAAB-000126For the determination of p53 protein from human tissue, cell lines and other samples (Catalog #: AB000126)
Anti-human IgG ELISA KitAB000303The anti-human IgG ELISA kit is designed to quantitatively measure human IgG levels in biological samples.
Horse Radish Peroxidase (HRP) stabilizer (50 ml)AB000804For the stabilization and long term storage of low and high concentrations of Horse Radish Peroxidase (Catalog # AB000804)
One-Step TMB substrate (250 ml)AB000801For easy detection of HRP activities in ELISA analysis (Catalog # AB000801)
One-Step Enhanced TMB substrate (250 ml)AB000802For highly sensitive detection of HRP activities (Catalog # AB000802)
ELISA plate stabilizer (1000 ml)AB000803For the long term stabilization of coated ELISA plates (Catalog # AB000803)


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Biospacific.jpg


BiosPacific公司是R&D Systems 旗下专门为临床诊断试剂的研发与生产提供抗原、抗体(多抗、单抗、偶联的抗体、抗体对)的公司,在临床诊断试剂方面非常著名,是临床诊断试剂原料的全球供应商。BiosPacific公司是全球著名的临床诊断抗原抗体原料的供应商,其产品主要集中在癌症(肿瘤)、内分泌、传染病、人血清蛋白、甾类、血管病等标记物的优质单抗、多抗、抗原、偶联抗体,以及抗体对(matched pairs)。

 

As a manufacturer and supplier of antibodies and antigens of exceptional quality, for more than 29 years, BiosPacific is experienced in meeting the rigorous demands of the industrial client. Our success has been due, in large part, to our commitment to find the most effective solutions for your individual needs. Our expansive range of monoclonal antibodies, affinity purified polyclonal antibodies and purified proteins for immunoassay development allows us to support our customers collaboratively from feasibility to manufacturing. Browse by subject category such as cancer or cardiac markers below, or do a keyword search using the search field above.

 

BIOSPACIFIC产品的主要涵盖领域:

(1)Cancer

AFP, Alpha-2 Macroglobulin, Beta-2 Microglobulin, CA 125

(2)Endocrine Thyroid

ACTH, FSH, hCG, hGH, IGF-1, Insulin, LH, Proinsulin

(3)Steroids

Cortisol, Estradiol, Progesterone, Testosterone

(4)Cardio-vascular

CKBB, CKMB, CKMM, CRP, D-dimer, Myoglobin, TNI

(5)Human Serum Proteins

Albumin, Alpha-1 Antitrypsin, APO E,CRP, Hemoglobin

(6)Miscellaneous

Ferritin, Glucagon, IgE Myeloma Plasma, Stripped Serums, TPO

(7)Drugs

Amikacin, Amphetamine, Barbiturate, Benzodiazepine

(8)Infectious Diseases

Adenovirus, Chlamydia, CMV, Influenza A & B, HAV, HBcAg, Zika

(9)Medix Biochemica

AFP, CEA, CKMB, IgA, Myoglobin, RSV, SHBG, TSH

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